Genetic testing can help to determine an individual’s sensitivity to warfarin and help to decrease the amount of time necessary to achieve a stable INR. The following genes contain important information regarding an individual’s warfarin sensitivity: CYP2C9, VKORC1, CYP4F2 and GGCX. CYP2C9 gene The CYP2C9 gene encodes the Cytochrome P450 2C9 enzyme, which is responsible [...]
International Normalized Ratio (INR) is a blood test used to determine the correct dose of warfarin, and monitor its anticoagulant effects. The higher the INR, the longer time it will take to clot, leading to a higher risk of bleeding. Warfarin has a narrow therapeutic range, and requires an INR of 2-3 in order to [...]
Warfarin is an effective medication commonly used for preventing blood clots, but the correct dosage to administer can vary among different individuals. Determining the correct warfarin dose is important for safety and effectiveness, as excess warfarin in blood can result in severe bleeding, while insufficient warfarin will not effectively protect against abnormal blood clotting. Administering [...]
Warfarin is an anticoagulant used to prevent abnormal blood clot formation. An anticoagulant is a type of medication that decreases the blood’s ability to clot. Normally, a blood clot forms in response to wounds to help stop bleeding and prevent further blood loss. However, if a blood clot forms within blood vessels, it can block [...]